Long non-coding RNAs: Potential therapeutic targets for epilepsy

Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate...

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Published inFrontiers in neuroscience Vol. 16; p. 986874
Main Authors Liu, Sen, Fan, Min, Ma, Meng-Die, Ge, Jin-Fang, Chen, Fei-Hu
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.10.2022
Subjects
apoptosis
drug discovery
epilepsy
GABA
lncRNAs
neuroinflammation
Neuroscience
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Summary:Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide. Long non-coding RNAs (LncRNAs) are a class of RNAs longer than 200 nucleotides without the capacity of protein coding, but they participate in a wide variety of pathophysiological processes. Alternated abundance and diversity of LncRNAs have been found in epilepsy patients and animal or cell models, suggesting a potential role of LncRNAs in epileptogenesis. This review will introduce the structure and function of LncRNAs, summarize the role of LncRNAs in the pathogenesis of epilepsy, especially its linkage with neuroinflammation, apoptosis, and transmitter balance, which will throw light on the molecular mechanism of epileptogenesis, and accelerate the clinical implementation of LncRNAs as a potential therapeutic target for treatment of epilepsy.
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Edited by: Ying Xu, University at Buffalo, United States
This article was submitted to Neuropharmacology, a section of the journal Frontiers in Neuroscience
Reviewed by: Santosh Kumar, National Institute of Technology Rourkela, India; Chen-wei Wang, University of Science & Technology Chittagong, Bangladesh; Zhi Zhang, Fudan University, China
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.986874