Apigenin-Mn(II) loaded hyaluronic acid nanoparticles for ulcerative colitis therapy in mice

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease characterized by rapid progression and frequent comorbidities that make its treatment challenging. Nanomaterial-based strategies have been extensively studied to target the GI mucosal immune system in recent years. Herein, we...

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Published inFrontiers in chemistry Vol. 10; p. 969962
Main Authors Lv, Feng, Zhang, Yuchen, Peng, Qiao, Zhao, Xinxin, Hu, Datao, Wen, Jinpeng, Liu, Kailai, Li, Ruilin, Wang, Ke, Sun, Jinyao
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.07.2022
Subjects
API-Mn(II) complex
Chemistry
DSS
manganese ion
regulatory effect
ulcerative colitis
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Summary:Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease characterized by rapid progression and frequent comorbidities that make its treatment challenging. Nanomaterial-based strategies have been extensively studied to target the GI mucosal immune system in recent years. Herein, we propose a novel apigenin-Mn(II) loaded sodium hyaluronate nanoparticles where apigenin (API) was incorporated in the Mn 2+ ramework, coated with hyaluronic acid. The apigenin-Mn(II) loaded sodium hyaluronate nanoparticles (API-Mn(II)@HA NPs) exhibited a diameter of 200 nm and were effective against UC. The preparation of the API-Mn(II) complex was relatively simple, and the mechanism underlying its therapeutic effect on UC induced by sodium dextran sulfate (DSS) was studied in detail. We found that API-Mn(II)@HA nanoparticles could effectively repair the intestinal barrier and significantly improve the damaged colon tissue by mediating inflammatory factors. This study provides novel insights on a new kind of active targeted nanoparticle for improving the efficacy of drugs for UC treatment.
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Reviewed by: Jianxun Ding, Changchun Institute of Applied Chemistry (CAS), China
Edited by: Botao Song, Northwest University, China
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
These authors share first authorship
Xiaoyou Wang, Southwest University, China
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.969962