Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of Inactivation and Neurochemical Modulation of Ventrolateral Prefrontal Cortex

• Published in: The Journal of neuroscience Vol. 41; no. 34; pp. 7246 - 7258
• Main Authors: Axelsson, S F A, Horst, N K, Horiguchi, Naotaka, Roberts, A C, Robbins, T W
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 25.08.2021
• Subjects: Accuracy; Animals; Antipsychotic Agents - adverse effects; Arrays; Baclofen - pharmacology; Callithrix; Cognition Disorders - chemically induced; Cognitive ability; Deactivation; Dopamine; Dopamine - physiology; Dopamine D2 Receptor Antagonists - pharmacology; Dopamine D2 receptors; Errors; Excitotoxicity; Fluorobenzenes - pharmacology; GABA Agonists - pharmacology; gamma-Aminobutyric Acid - physiology; Goals; Inactivation; Medical imaging; Memory, Short-Term - physiology; Muscimol - pharmacology; Neuroimaging; Neuromodulation; Piperidines - pharmacology; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiology; Psychomotor Performance - drug effects; Psychomotor Performance - physiology; Receptors; Serotonin - physiology; Serotonin 5-HT2 Receptor Antagonists - pharmacology; Serotonin S2 receptors; Spatial Behavior; Sulpiride - pharmacology; γ-Aminobutyric acid; response sequencing; marmoset; prefrontal cortex; ventrolateral prefrontal cortex; D2; 5-HT2A

Previously, studies using human neuroimaging and excitotoxic lesions in non-human primate have demonstrated an important role of ventrolateral prefrontal cortex (vlPFC) in higher order cognitive functions such as cognitive flexibility and the planning of behavioral sequences. In the present experime...