The scalp cooling therapy for hair loss in breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis

• Published in: Supportive care in cancer Vol. 29; no. 11; pp. 6943 - 6956
• Main Authors: Wang, Shurui, Yang, Ting, Shen, Aomei, Qiang, Wanmin, Zhao, Zihan, Zhang, Fangyuan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2021; Springer; Springer Nature B.V
• Subjects: Alopecia; Analysis; Baldness; Breast cancer; Cancer; Cancer patients; Chemotherapy; Clinical outcomes; Cooling; Cross-sectional studies; Hair loss; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Meta-analysis; Nursing; Nursing Research; Oncology; Pain Medicine; Rehabilitation Medicine; Review Article; Side effects; Therapy; Adverse effects; Scalp cooling; Chemotherapy-induced alopecia; Breast neoplasm; Meta-analysis
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-021-06188-8

Purpose To systematically assess the efficacy and side effects of scalp cooling in patients with breast cancer. Methods A systematic literature search was conducted in October 2020 across Cochrane Library, PubMed, Embase, CINAHL, Web of Science, Scopus, and four Chinese databases (CNKI, Wanfang, SinoMed, and VIP database). Our review included all randomized controlled trials, cohort studies, and cross-sectional studies. Two authors independently searched databases, screened studies, extracted data, and evaluated each included study’s methodological quality and risk bias. Meta-analysis was performed using Stata 15.1 software package and Revman 5.3 software, with estimates of scalp cooling effect and its side effects from pooled using a random-effects model. This study has been registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42020216224). Results In total, 755 articles were screened and data from 27 studies involving 2202 participants were used in the meta-analysis. Studies meeting inclusion and exclusion criteria were three randomized clinical trials, 12 cohort studies, and 12 cross-sectional studies. The effectiveness rate of using a scalp cooling device to protect hair was 61% (95% CI: 55 to 67%, I 2 = 88%, P = 0.000). However, scalp cooling therapy’s side effects are not be ignored, such as headache, dizziness, scalp pain, neck pain, feeling cold, heaviness of the head, skin rash, nausea, and overtightened strap. Conclusions This review shows that scalp cooling devices can significantly improve the patients with breast cancer chemotherapy–induced alopecia, but the implications of its side effects provide guide for the implementation of this technology.