Outcomes of Neonates Born to Mothers With Coronavirus Disease 2019 (COVID-19) — National Neonatology Forum (NNF) India COVID-19 Registry

• Published in: Indian pediatrics Vol. 58; no. 6; pp. 525 - 531
• Main Authors: Kumar, Praveen, More, Kiran, Chawla, Deepak, Murki, Srinivas, Tandur, Baswaraj, Deorari, Ashok K., Dontamala, Suchitra, Sundaram, Mangalabharathi, Anitha, M., Laxmikant, Deshmukh, Mallick, Asim Kumar, Dalal, Jagjit Singh, Verma, Ankit, Kumar, R. Vinay, Kalane, Shilpa, Das, Ratan K., Som, Tapas Kumar, Ray, Somosri, Mittal, Manish, Mehta, Ashish, Natarajan, Chandra Kumar, Aradhya, Abhishek, Patel, Niraj, George, J. N., Sandanala, Srikanth, Sajjid, Mohammed, Subramanian, Vijaya, Manikumar, S., Maity, Debasis, Dayanand, Sandeep Jhajra, Balasundar, Joshi, Rajan V., Mohanty, Pankaj Kumar, Sahoo, Tanushree, Munian, Dinesh, Shah, Binoy, Vijayakumar, Vaanathi
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.06.2021
• Subjects: Maternal and Child Health; Medicine; Medicine & Public Health; Pediatric Surgery; Pediatrics; Research Paper; Risk; Horizontal transmission; Perinatal transmission; Outcome
• ISSN: 0019-6061; 0974-7559
• DOI: 10.1007/s13312-021-2234-2

Background Limited evidence exists on perinatal transmission and outcomes of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in neonates. Objective To describe clinical outcomes and risk factors for transmission in neonates born to mothers with perinatal SARS-CoV-2 infection. Design Prospective cohort of suspected and confirmed SARS-CoV-2 infected neonates entered in National Neonatology Forum (NNF) of India registry. Subjects Neonates born to women with SARS-CoV-2 infection within two weeks before or two days after birth and neonates with SARS-CoV-2 infection. Outcomes Incidence and risk factors of perinatal transmission. Results Among 1713 neonates, SARS-CoV-2 infection status was available for 1330 intramural and 104 extramural neonates. SARS-CoV-2 positivity was reported in 144 intramural and 39 extramural neonates. Perinatal transmission occurred in 106 (8%) and horizontal transmission in 21 (1.5%) intramural neonates. Neonates roomed-in with mother had higher transmission risk (RR1.16, 95% CI 1.1 to 2.4; P =0.01). No association was noted with the mode of delivery or type of feeding. The majority of neonates positive for SARS-CoV2 were asymptomatic. Intramural SARS-CoV-2 positive neonates were more likely to be symptomatic (RR 5, 95%CI 3.3 to 7.7; P <0.0001) and need resuscitation (RR 2, 95%CI 1.0 to 3.9; P =0.05) compared to SARS-CoV-2 negative neonates. Amongst symptomatic neonates, most morbidities were related to prematurity and perinatal events. Conclusion Data from a large cohort suggests perinatal transmission of SARS-CoV-2 infection and increased morbidity in infected infants.