Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications
Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host cell, impacts intracellular immunity through...
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| Published in | Frontiers in genetics Vol. 12; p. 693227 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
06.09.2021
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host cell, impacts intracellular immunity through the IFN-I signaling, and growth pathways through the mitogen-activated protein kinases (MAPKs). In this mini-review, we analyze the main structural similarities of ORF8 with immunological molecules such as IL−1, contributing to the immunological deregulation observed in COVID-19. We also propose that the blockage of some effector functions of ORF8 with Rapamycin, such as the mTORC1 activation through MAPKs 40 pathway, with Rapamycin, can be a promising approach to reduce COVID-19 mortality. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Dariusz Plewczynski, Warsaw University of Technology, Poland This article was submitted to Computational Genomics, a section of the journal Frontiers in Genetics Reviewed by: Sandra Paulina Smieszek, Vanda Pharmaceuticals Inc., United States; Pragati Agnihotri, Advanced BioScience Laboratories, Inc. (ABL), United States |
| ISSN: | 1664-8021 1664-8021 |
| DOI: | 10.3389/fgene.2021.693227 |