Bacterial genome variability and its impact on vaccine design

The majority of currently available successful vaccines induce host responses against antigens that are highly conserved in the targeted pathogens. The diphtheria, tetanus, and pertussis vaccines confer protection by inducing neutralizing antibodies to the conserved bacterial toxins that are the maj...

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Bibliographic Details
Published inCell host & microbe Vol. 3; no. 6; pp. 408 - 416
Main Author Telford, John L
Format Journal Article
LanguageEnglish
Published United States 01.06.2008
Subjects
Animals
Antigenic Variation
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Bacteria
Bacteria - genetics
Bacteria - immunology
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Bacterial Vaccines - genetics
Bacterial Vaccines - immunology
Gene Expression
Genetic Variation
Genome, Bacterial
Hemophilus influenzae
Humans
Polysaccharides, Bacterial - genetics
Polysaccharides, Bacterial - immunology
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Summary:The majority of currently available successful vaccines induce host responses against antigens that are highly conserved in the targeted pathogens. The diphtheria, tetanus, and pertussis vaccines confer protection by inducing neutralizing antibodies to the conserved bacterial toxins that are the major virulence factors. The Hemophilus influenzae B vaccine induces responses to conserved epitopes in the sugar structure of the bacterial capsular polysaccharide. However, the efficacy of more recently developed vaccines is limited by antigen variation, which also presents a challenge for future vaccine development. This review will explore bacterial genome variability and its impact on vaccine development.
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ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2008.05.004