Contribution of gut microbiota toward renal function in sepsis

Sepsis most often involves the kidney and is one of the most common causes of acute kidney injury. The prevalence of septic acute kidney injury has increased significantly in recent years. The gut microbiota plays an important role in sepsis. It interacts with the kidney in a complex and multifactor...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in microbiology Vol. 13; p. 985283
Main Authors Xu, Yaya, Kong, Xiangmei, Zhu, Yueniu, Xu, Jiayue, Mao, Haoyun, Li, Jiru, Zhang, Jianhua, Zhu, Xiaodong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.09.2022
Subjects
augmented renal clearance
gut micro flora
gut–kidney crosstalk
intestinal microbiology
Microbiology
sepsis
Online AccessGet full text

Cover

More Information
Summary:Sepsis most often involves the kidney and is one of the most common causes of acute kidney injury. The prevalence of septic acute kidney injury has increased significantly in recent years. The gut microbiota plays an important role in sepsis. It interacts with the kidney in a complex and multifactorial process, which is not fully understood. Sepsis may lead to gut microbiota alteration, orchestrate gut mucosal injury, and cause gut barrier failure, which further alters the host immunological and metabolic homeostasis. The pattern of gut microbiota alteration also varies with sepsis progression. Changes in intestinal microecology have double-edged effects on renal function, which also affects intestinal homeostasis. This review aimed to clarify the interaction between gut microbiota and renal function during the onset and progression of sepsis. The mechanism of gut–kidney crosstalk may provide potential insights for the development of novel therapeutic strategies for sepsis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors have contributed equally to this work and share co-corresponding authors
This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
Edited by: Khalid Mehmood, Islamia University of Bahawalpur, Pakistan
These authors have contributed equally to this work and share first authorship
Reviewed by: Blanda Di Luccia, Stanford University, United States; Wei Yan, National Institutes of Health, United States; Selçuk Yüksel, Pamukkale University, Turkey
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.985283