Corresponding anatomical of the macaque superior parietal lobule areas 5 (PE) subdivision reveal similar connectivity patterns with humans

• Published in: Frontiers in neuroscience Vol. 16; p. 964310
• Main Authors: Wang, Qianshan, Wang, Yue, Xu, Wenyi, Chen, Xiaofeng, Li, Xueqi, Li, Qi, Li, Haifang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.10.2022
• Subjects: brain region homology; brain region subdivision; cross-species comparison; diffusion tensor imaging; Neuroscience; superior parietal lobule (SPL)
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2022.964310

Using the animal brain as a cross-species tool for human brain research based on imaging features can provide more potential to reveal comprehensive human brain analysis. Previous studies have shown that human Brodmann area 5 (BA5) and macaque PE are homologous regions. They are both involved in processes depth and direction information during the touch process in the arm movement. However, recent studies show that both BA5 and PE are not homogeneous. According to the cytoarchitecture, BA5 is subdivided into three different subregions, and PE can be subdivided into PEl, PEla, and PEm. The species homologous relationship among the subregions is not clear between BA5 and PE. At the same time, the subdivision of PE based on the anatomical connection of white matter fiber bundles needs more verification. This research subdivided the PE of macaques based on the anatomical connection of white matter fiber bundles. Two PE subregions are defined based on probabilistic fiber tracking, one on the anterior side and the other on the dorsal side. Finally, the research draws connectivity fingerprints with predefined homologous target areas for the BA5 and PE subregions to reveal the characteristics of structure and functions and gives the homologous correspondence identified.