Thrombin and Platelet Activation

The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as proteas...

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Bibliographic Details
Published inChest Vol. 124; no. 3; pp. 18S - 25S
Main Author Brass, Lawrence F.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2003
American College of Chest Physicians
Subjects
Adenosine diphosphate
Blood platelets
Blood Platelets - physiology
Collagen
G protein-coupled receptors
G proteins
Humans
Injuries
Nitric oxide
phospholipase C
platelet
Platelet Activation - physiology
protease-activated receptors
Proteins
Receptors, Thrombin - physiology
thrombin
Thrombin - physiology
phospholipase C
protease-activated receptors
PAR
NO
GTP
G protein-coupled receptors
thrombin
VWF
PGI2
GP
cAMP
ADP
GDP
TxA2
platelet
GPCR
G proteins
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Summary:The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can participate in the growth of an immobile hemostatic plug. How this is accomplished is the subject of this review.
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ISSN:0012-3692
1931-3543
DOI:10.1378/chest.124.3_suppl.18S