Epigenetic regulation of synaptic disorder in Alzheimer’s disease
Synapses are critical structures involved in neurotransmission and neuroplasticity. Their activity depends on their complete structure and function, which are the basis of learning, memory, and cognitive function. Alzheimer’s disease (AD) is neuropathologically characterized by synaptic loss, synapt...
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Published in | Frontiers in neuroscience Vol. 16; p. 888014 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
03.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Synapses are critical structures involved in neurotransmission and neuroplasticity. Their activity depends on their complete structure and function, which are the basis of learning, memory, and cognitive function. Alzheimer’s disease (AD) is neuropathologically characterized by synaptic loss, synaptic disorder, and plasticity impairment. AD pathogenesis is characterized by complex interactions between genetic and environmental factors. Changes in various receptors on the postsynaptic membrane, synaptic components, and dendritic spines lead to synaptic disorder. Changes in epigenetic regulation, including DNA methylation, RNA interference, and histone modification, are closely related to AD. These can affect neuronal and synaptic functions by regulating the structure and expression of neuronal genes. Some drugs have ameliorated synaptic and neural dysfunction in AD models
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epigenetic regulation. We reviewed the recent progress on pathological changes and epigenetic mechanisms of synaptic dysregulation in AD to provide a new perspective on this disease. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Salvatore Fusco, Catholic University of the Sacred Heart, Rome, Italy; Nicodemus Edrick Oey, Duke-NUS Medical School, Singapore This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience These authors have contributed equally to this work Edited by: Athanasios Metaxas, European University Cyprus, Cyprus |
ISSN: | 1662-453X 1662-4548 1662-453X |
DOI: | 10.3389/fnins.2022.888014 |