Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation

A short review of biophysical mechanisms for electrotransfer of biaoctive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed....

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Bibliographic Details
Published inEuropean biophysics journal Vol. 44; no. 5; pp. 277 - 289
Main Authors Venslauskas, Mindaugas S., Šatkauskas, Saulius
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2015
Springer Nature B.V
Subjects
Animals
Biochemistry
Biological activity
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Cell Biology
Cell Membrane - chemistry
Cell Membrane - metabolism
Cell Membrane Permeability
Cellular biology
Electroporation
Humans
Life Sciences
Membrane Biology
Membranes
Nanotechnology
Neurobiology
Organic Chemicals - pharmacokinetics
Review
Drug and gene electrotransfer
Electroporation modeling
Electrotransfer mechanisms
Electrochemotherapy
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Summary:A short review of biophysical mechanisms for electrotransfer of biaoctive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0175-7571
1432-1017
DOI:10.1007/s00249-015-1025-x