A Glimpse Into the Microbiome of Sjögren’s Syndrome

Sjögren’s syndrome (SS) is a common chronic systemic autoimmune disease and its main characteristic is lymphoid infiltration of the exocrine glands, particularly the salivary and lacrimal glands, leading to sicca symptoms of the mouth and eyes. Growing evidence has shown that SS is also characterize...

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Published inFrontiers in immunology Vol. 13; p. 918619
Main Authors Deng, Chuiwen, Xiao, Qiufeng, Fei, Yunyun
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 14.07.2022
Subjects
autoimmunity
Immunology
inflammation
microbiome
pathogenesis
Sjogren’s syndrome
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Summary:Sjögren’s syndrome (SS) is a common chronic systemic autoimmune disease and its main characteristic is lymphoid infiltration of the exocrine glands, particularly the salivary and lacrimal glands, leading to sicca symptoms of the mouth and eyes. Growing evidence has shown that SS is also characterized by microbial perturbations like other autoimmune diseases. Significant alterations in diversity, composition, and function of the microbiota were observed in SS. The dysbiosis of the microbiome correlates with worse symptoms and higher disease severity, suggesting that dysbiosis may be of great importance in the pathogenesis of SS. In this review, we provide a general view of recent studies describing the microbiota alterations of SS, the possible pathways that may cause microbiota dysbiosis to trigger SS, and the existence of the gut-ocular/gut-oral axis in SS.
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Reviewed by: Koichiro Irie, Meikai University, Japan; Xiaoli Deng, Beijing Jishuitan Hospital, China
Edited by: Aleksandar David Kostic, Harvard Medical School, United States
These authors have contributed equally to this work
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.918619