Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

• Published in: Current breast cancer reports Vol. 10; no. 1; pp. 14 - 27
• Main Authors: Seiler, Annina, Chen, Michelle A., Brown, Ryan L., Fagundes, Christopher P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2018
• Subjects: Internal Medicine; Medicine; Medicine & Public Health; Oncology; Psycho-Oncology and Supportive Care (E Shinn and C Fagundes; Section Editors; Surgical Oncology; Topical Collection on Psycho-Oncology and Supportive Care; Obesity; Breast cancer risk; Dietary patterns; Inflammation; Nutrition; Survival
• ISSN: 1943-4588; 1943-4596
• DOI: 10.1007/s12609-018-0264-0

Purpose of Review To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk. Recent Findings Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality. Summary Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.