Serum leptin is associated with serum uric acid concentrations in humans

• Published in: Metabolism, clinical and experimental Vol. 48; no. 6; pp. 677 - 680
• Main Authors: Fruehwald-Schultes, Bernd, Peters, Achim, Kern, Werner, Beyer, Jürgen, Pfützner, Andreas
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.1999; Elsevier
• Subjects: Adipose Tissue - metabolism; Analysis of Variance; Biological and medical sciences; Body Constitution; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Female; Humans; Hypertension - blood; Leptin; Linear Models; Lipoproteins - blood; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - blood; Proteins - metabolism; Sex Factors; Syndrome; Triglycerides - blood; Uric Acid - blood; Human; Obesity; Nutrition disorder; Biological marker; Metabolic diseases; Lipids; Uric acid; Fat mass; Body mass index; Hyperuricemia; Leptin; Purine; Dyslipemia; Nutritional status
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/S0026-0495(99)90163-4

This cross-sectional study aimed to evaluate the relationship between leptin and the cluster of abnormalities often referred to as the metabolic syndrome. The serum leptin concentration, body mass index (BMI), percent body fat, total fat mass (FM), waist and hip circumference, waist to hip ratio (WHR), prevalence of hypertension, and triglyceride (TG), lipoprotein, and uric acid concentration were determined in 86 type 2 diabetic (n = 59) and healthy (n = 27) subjects. Multiple regression analyses showed that the estimates of total body obesity (BMI, percent body fat, and total FM), sex, and serum uric acid concentration are independently associated with the serum leptin concentration. The finding of a positive correlation between serum leptin and uric acid levels suggests that leptin could be a pathogenic factor responsible for hyperuricemia in obesity.