How Do Pollen Allergens Sensitize?

• Published in: Frontiers in molecular biosciences Vol. 9; p. 900533
• Main Authors: Guryanova, Svetlana V., Finkina, Ekaterina I., Melnikova, Daria N., Bogdanov, Ivan V., Bohle, Barbara, Ovchinnikova, Tatiana V.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 16.06.2022
• Subjects: allergen; allergen-specific antibody; ligand-allergen interaction; lipids; Molecular Biosciences; pollen; sensitization
• ISSN: 2296-889X; 2296-889X
• DOI: 10.3389/fmolb.2022.900533

Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system. In this review, special attention is paid not only to properties of allergens but also to an important role of their interaction with lipids and other hydrophobic molecules in pollen sensitization. The reactions of epithelial cells lining the nasal and bronchial mucosa and of other immunocompetent cells will also be considered, in particular the mechanisms of the activation of B and T lymphocytes and the formation of allergen-specific antibody responses.