Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In C...
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Published in | Frontiers in cellular and infection microbiology Vol. 12; p. 814668 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
21.06.2022
|
Subjects | |
Online Access | Get full text |
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Summary: | Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women,
L. gasseri–
dominated and
L. jensenii–
dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including
Streptococcus
,
Prevotella
,
Chlamydia
,
Bifidobacterium
,
Ralstonia
, and
Aerococcus.
With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Jaime Garcia-Mena, Instituto Politécnico Nacional de México (CINVESTAV), Mexico These authors have contributed equally to this work and share first authorship This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology Reviewed by: Simone Filardo, Sapienza University of Rome, Italy; Miriam Enriqueta Nieves Ramirez, National Autonomous University of Mexico, Mexico These authors have contributed equally to this work and share last authorship |
ISSN: | 2235-2988 2235-2988 |
DOI: | 10.3389/fcimb.2022.814668 |