Circulating oxidized LDL, measured with FOH1a/DLH3 antibody, is associated with metabolic syndrome and the coronary heart disease risk score in healthy Japanese

• Published in: Atherosclerosis Vol. 203; no. 1; pp. 243 - 248
• Main Authors: Ueba, Tetsuya, Nomura, Shosaku, Nishikawa, Tomofumi, Kajiwara, Motohiro, Yamashita, Kohsuke
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2009
• Subjects: Adult; Aged; Antibodies, Monoclonal - chemistry; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnosis; Cardiovascular; Coronary Disease - blood; Coronary Disease - diagnosis; Coronary heart disease risk score; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Japan; Lipoproteins, LDL - blood; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Middle Aged; Odds Ratio; oxLDL; Risk; oxLDL; Metabolic syndrome; Coronary heart disease risk score; Atherosclerosis
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2008.05.048

Abstract Background and purpose The objective of this study was to clarify the relationship between circulating oxidized LDL (oxLDL) and metabolic syndrome (MS) and the coronary heart disease (CHD) risk score. Methods We conducted a cross-sectional study of healthy volunteers who had no signs, symptoms or history of cardiovascular or cerebrovascular disease and took no medications. We studied 382 Japanese volunteers, 190 men and 192 women (median age 41 and 38 years, respectively). We used an ELISA kit and a monoclonal oxLDL antibody, FOH1a/DLH3, to measure circulating oxLDL. Results The odds ratio (OR) for elevated oxLDL in individuals with MS compared to those without MS, adjusted for age and sex, was 1.94 (range 1.00–3.78). In individuals with a predicted Framingham 10-year risk for CHD > 5% (corresponding with the highest quartile), compared to those with a predicted 10-year risk < 5%, the OR, adjusted for age, sex, smoking, and LDL cholesterol, was 2.51 (1.17–5.36). The age-, sex-, smoking- and LDL cholesterol-adjusted OR for a 10-year CHD risk score >5% was 1.03 (1.01–1.04) for LDL cholesterol and 11.7 (4.69–29.0) for smoking. Conclusions Elevated oxLDL is associated with the presence of MS and the CHD risk score in healthy people.