Role of C5a-C5aR axis in the development of atherosclerosis

• Published in: Science China. Life sciences Vol. 57; no. 8; pp. 790 - 794
• Main Authors: An, GuiPeng, Ren, GuoRui, An, FengShuang, Zhang, Cheng
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.08.2014; Springer Nature B.V
• Subjects: Animals; Atherosclerosis - blood; Atherosclerosis - physiopathology; Biomedical and Life Sciences; Complement C5a - chemistry; Complement C5a - metabolism; Complement C5a - physiology; Humans; Life Sciences; Prognosis; Receptor, Anaphylatoxin C5a - chemistry; Receptor, Anaphylatoxin C5a - physiology; Review; Structure-Activity Relationship; 人体器官; 免疫应答; 动脉硬化; 动脉粥样硬化; 实验动物模型; 生物效应; 血管疾病; 轴线; atherosclerosis; C5a receptors; C5a
• ISSN: 1674-7305; 1869-1889; 1869-1889
• DOI: 10.1007/s11427-014-4711-5

Complement component 5a（C5a）is a 74 amino acid glycoprotein and an important proinflammatory mediator that is cleaved enzymatically from its precursor,C5,on activation of the complement cascade.C5a is quickly metabolised by carboxypeptidases,forming the less-potent C5a desArg.C5a and C5a desArg interact with their receptors（C5aR and C5L2）,which results in a number of effects which are essential to the immune response.C5a has a broad range of biological effects throughout the human body because the widespread expression of C5a receptors throughout the human organs enables C5a and C5a desArg to elicit a broad range of biological effects.Recently,accumulating evidence in humans and experimental animal models shows that the C5a-C5aR axis is involved in the development of atherosclerosis lesions.The absence or blockade of C5aRs greatly reduces the formation of atherosclerotic lesions or wire-injury-induced neointima formation in atherosclerosis-prone mice.Serum C5a level was related to the major adverse cardiovascular events in patients with advanced atherosclerosis and those with drug-eluting stent implantation.Thus,the C5a-C5aR axis may be a significant pathogenic driver of arteriosclerotic vascular disease,making C5a-C5aR inhibition an attractive therapeutic strategy.