KSHV Reprogramming of Host Energy Metabolism for Pathogenesis

Reprogramming of energy metabolism is a key for cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. Cancer cell energy metabolism is mainly dominated b...

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Published inFrontiers in cellular and infection microbiology Vol. 11; p. 621156
Main Authors Liu, Xiaoqing, Zhu, Caixia, Wang, Yuyan, Wei, Fang, Cai, Qiliang
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 12.05.2021
Subjects
Cellular and Infection Microbiology
energy metabolism
herpesvirus
KSHV
oncogenesis
viral reprogramming
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Summary:Reprogramming of energy metabolism is a key for cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers.
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This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Arunava Roy, University of South Florida, United States; Fanxiu Zhu, State College of Florida, Manatee–Sarasota, United States
Edited by: Subhash C. Verma, University of Nevada, United States
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.621156