Anti-leucine-rich Glioma-inactivated 1 Encephalitis Manifesting as Frequent Ictal Pouting and Subtle Memory Disturbance

Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis is a treatable form of limbic encephalitis, marked by frequent focal seizures and cognitive decline (particularly memory disturbance); however, it can be difficult to diagnose in patients with subtle cognitive decline. Ictal pouting, a rare...

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Bibliographic Details
Published inInternal Medicine p. 4025-24
Main Authors Araki, Takeshi, Yoshimura, Hajime, Tsuchida, Kenta, Hatanaka, Noriko, Kawamoto, Michi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 2024
Subjects
Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis
cognitive decline
ictal pouting
memory disturbance
memory disturbance
Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis
cognitive decline
ictal pouting
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Summary:Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis is a treatable form of limbic encephalitis, marked by frequent focal seizures and cognitive decline (particularly memory disturbance); however, it can be difficult to diagnose in patients with subtle cognitive decline. Ictal pouting, a rare seizure feature, has not yet been reported in anti-LGI1 encephalitis. A 73-year-old man with anti-LGI1 encephalitis presented with subacute onset of frequent ictal pouting without apparent cognitive decline. Steroid treatment alone resolved seizures and improved subtle visual memory. Middle-aged and older patients experiencing subacute-onset frequent focal seizures should be thoroughly evaluated for memory disturbances to determine the need for anti-LGI1 antibody measurement.
Bibliography:ObjectType-Article-1
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ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.4025-24