Comparative Genomic Data Provide New Insight on the Evolution of Pathogenicity in Sporothrix Species
Sporothrix species are commonly isolated from environmental and clinical samples. As common causes of zoonotic mycosis, Sporothrix species may result in localized or disseminated infections, posing considerable threat to animal and human health. However, the pathogenic profiles of different Sporothr...
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Published in | Frontiers in microbiology Vol. 11; p. 565439 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
30.09.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Sporothrix
species are commonly isolated from environmental and clinical samples. As common causes of zoonotic mycosis,
Sporothrix
species may result in localized or disseminated infections, posing considerable threat to animal and human health. However, the pathogenic profiles of different
Sporothrix
species varied, in virulence, geographic location and host ranges, which have yet to be explored. Analysing the genomes of
Sporothrix
species are useful for understanding their pathogenicity. In this study, we analyzed the whole genome of 12
Sporothrix
species and six
S. globosa
isolates from different clinical samples in China. By combining comparative analyses with Kyoto Encyclopedia of Genes and Genomes (KEGG), Carbohydrate-Active enZymes (CAZy), antiSMASH, Pfam, and PHI annotations,
Sporothrix
species showed exuberant primary and secondary metabolism processes. The genome sizes of four main clinical species, i.e.,
S. brasiliensis
,
S. schenckii
,
S. globosa
, and
S. luriei
were significantly smaller than other environmental and clinical
Sporothrix
species. The contracted genes included mostly CAZymes and peptidases genes that were usually associated with the decay of plants, as well as the genes that were associated with the loss of pathogenicity and the reduced virulence. Our results could, to some extent, explain a habitat shift of
Sporothrix
species from a saprobic life in plant materials to a pathogenic life in mammals and the increased pathogenicity during the evolution. Gene clusters of melanin and clavaric acid were identified in this study, which improved our understanding on their pathogenicity and possible antitumor effects. Moreover, our analyses revealed no significant genomic variations among different clinical isolates of
S. globosa
from different regions in China. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Qunfeng Dong, Stritch School of Medicine, Loyola University Chicago, United States Reviewed by: G. Sybren De Hoog, Radboud University Nijmegen Medical Centre, Netherlands; Ruoyu Li, Peking University First Hospital, China This article was submitted to Evolutionary and Genomic Microbiology, a section of the journal Frontiers in Microbiology |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2020.565439 |