MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer

• Published in: Tumor biology Vol. 35; no. 10; pp. 9815 - 9821
• Main Authors: Wang, Yu-zhou, Wu, Kun-peng, Wu, Ai-bing, Yang, Zhi-cheng, Li, Jin-mei, Mo, Yan-li, Xu, Meng, Wu, Bin, Yang, Zhi-xiong
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2014; Springer Nature B.V
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Correlation analysis; Female; Gene expression; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Matrix Metalloproteinase 14 - analysis; Matrix Metalloproteinase 14 - biosynthesis; Medical diagnosis; Middle Aged; Prognosis; Proportional Hazards Models; Research Article; Up-Regulation; Immunohistochemistry; Biomarker; Prognosis; Matrix metalloproteinase-14; Non-small cell lung cancer
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-014-2237-x

Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was to analyze the correlation between MMP-14 expression and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). Immunohistochemical staining for MMP-14 protein was performed in 104 patients with NSCLC. High levels of MMP-14 protein were positively correlated with the status of clinical stage (I–II vs. III–IV; P  < 0.001), N classification (N0–N1 vs. N2–N3; P  < 0.001), distant metastasis (no vs. yes; P  = 0.014), and differentiated degree (high vs. low or undifferentiated; P  = 0.001). The patients with higher MMP-14 expression of protein had shorter survival time than patients with low MMP-14 expression. Multivariate analysis indicated that the level of MMP-14 expression was an independent prognostic indicator ( P  < 0.001) for the survival of patients with NSCLC. In conclusion, MMP-14 is a potential unfavorable prognostic factor for patients with NSCLC.