Controlled release of antifungal drug terbinafine hydrochloride from poly( N-vinyl 2-pyrrolidone/itaconic acid) hydrogels

• Published in: International journal of pharmaceutics Vol. 228; no. 1; pp. 33 - 41
• Main Authors: Şen, Murat, Yakar, Arzu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 09.10.2001; Elsevier
• Subjects: Algorithms; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - administration & dosage; Antifungal Agents - chemistry; Biological and medical sciences; Chemistry, Pharmaceutical; Delayed-Action Preparations; Gels; General pharmacology; Hydrogels; Hydrogen-Ion Concentration; Medical sciences; Naphthalenes - administration & dosage; Naphthalenes - chemistry; pH-sensitive; Pharmaceutic Aids; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Poly( N-vinyl 2 pyrrolidone/itaconic acid); Povidone; Succinates; Terbinafine; Terbinafine hydrochloride; pH-sensitive; Hydrogels; Terbinafine hydrochloride; Poly( N-vinyl 2 pyrrolidone/itaconic acid); Pharmaceutical technology; Swelling; Controlled release form; Control release polymer; Drug carrier; In vitro; Itaconic derivative copolymer; Allylic compound; Terbinafine; Antifungal agent; Amine; Adsorption; Formulation; Dosage form; Pyrrolidone(vinyl) copolymer; pH; Active ingredient; Hydrogel; Release; Physicochemical properties
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/S0378-5173(01)00804-3

Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH-sensitive poly( N-vinyl 2-pyrrolidone/itaconic acid) P(VP/IA) hydrogels were investigated. P(VP/IA) hydrogels were prepared by irradiating the ternary monomer mixtures of N-vinyl 2-pyrrolidone/itaconic acid/ethylene glycol dimethacrylate in aqueous solution by γ-rays at ambient temperature. Hydrogels containing antifungal drug TER-HCl, at different drug-to-polymer ratios, were prepared by direct adsorption method. The influence of IA content in the gel on the adsorption capacities of hydrogels and the effect of pH on the releasing behavior of TER-HCl from the gel matrix were investigated. Terbinafine adsorption capacity of hydrogels was found to increase from 6 to 82 mg of TER-HCl per gram of dry gel with increasing drug concentration and amount of IA in the gel system. In-vitro drug-release studies in different buffer solutions showed that the basic parameters affecting the drug-release behavior of hydrogels are the pH of the solution and the IA content of the hydrogel.