Vitamin D Insufficiency and Deficiency in Children with Early Chronic Kidney Disease
Objective To assess the prevalence of abnormal vitamin D status in children and adolescents with chronic kidney disease (CKD). Study design This was an outpatient cross-sectional, retrospective study of 258 patients, mean age 12.3 ± 5.2 years, with an average estimated glomerular filtration rate (eG...
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Published in | The Journal of pediatrics Vol. 154; no. 6; pp. 906 - 911.e1 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Maryland Heights, MO
Mosby, Inc
01.06.2009
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Objective To assess the prevalence of abnormal vitamin D status in children and adolescents with chronic kidney disease (CKD). Study design This was an outpatient cross-sectional, retrospective study of 258 patients, mean age 12.3 ± 5.2 years, with an average estimated glomerular filtration rate (eGFR) of 106 ± 51 mL/min/1.73 m2 (range, 0 to 220 mL/min/1.73 m2 ). Serum 25-hydroxy-vitamin D [25(OH)D], calcium, phosphorus, and parathyroid hormone levels, as well as selected anthropometric variables, were analyzed. Results Reduced 25(OH)D concentrations (< 30 ng/mL) were found in 60% of the patients. In 28%, the concentration was < 20 ng/mL, indicating vitamin D deficiency. Patients with more advanced CKD were more likely to have vitamin D deficiency compared with those with incipient CKD or normal GFR (42% vs 26%; P = .03) and displayed more prominent hyperparathyroidism. Suboptimal vitamin D status was similar in males and females, but was significantly more prevalent in older ( P < .01), non-Caucasian ( P < .01), and overweight ( P = .02) patients. Patients with early-stage CKD (eGFR > 60 mL/min/1.73 m2 ) and with vitamin D deficiency were significantly shorter than their counterparts with 25(OH)D levels > 20 ng/mL ( P = .02). Conclusions Vitamin D insufficiency and deficiency are very prevalent in pediatric patients across all stages of CKD, particularly in non-Caucasian and obese patients, and may contribute to growth deficits during the earliest stages of CKD. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3476 1097-6833 |
DOI: | 10.1016/j.jpeds.2008.12.006 |