Acetylation in Tumor Immune Evasion Regulation

Acetylation is considered as one of the most common types of epigenetic modifications, and aberrant histone acetylation modifications are associated with the pathological process of cancer through the regulation of oncogenes and tumor suppressors. Recent studies have shown that immune system functio...

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Published inFrontiers in pharmacology Vol. 12; p. 771588
Main Authors Lu, Jun, He, Xiang, Zhang, Lijuan, Zhang, Ran, Li, Wenzheng
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.11.2021
Subjects
acetylases
acetylated modifications
cancer immunotherapy
deacetylases
Pharmacology
tumor immunity
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Summary:Acetylation is considered as one of the most common types of epigenetic modifications, and aberrant histone acetylation modifications are associated with the pathological process of cancer through the regulation of oncogenes and tumor suppressors. Recent studies have shown that immune system function and tumor immunity can also be affected by acetylation modifications. A comprehensive understanding of the role of acetylation function in cancer is essential, which may help to develop new therapies to improve the prognosis of cancer patients. In this review, we mainly discussed the functions of acetylase and deacetylase in tumor, immune system and tumor immunity, and listed the information of drugs targeting these enzymes in tumor immunotherapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Reviewed by: Ercan Cacan, Gaziosmanpaşa University, Turkey
Dapeng Dai, Beijing Hospital, China
These authors have contributed equally to this work and share first authorship
Edited by: Yi-Chao Zheng, Zhengzhou University, China
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.771588