Helicobacter pylori and unignorable extragastric diseases: Mechanism and implications
Considered as the most popular pathogen worldwide, Helicobacter pylori is intensively associated with diverse gastric diseases, including gastric ulcers, chronic progressive gastritis, and gastric cancer. Aside from its pathogenic effect on gastric diseases, growing evidences reveal that H. pylori m...
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Published in | Frontiers in microbiology Vol. 13; p. 972777 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
04.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Considered as the most popular pathogen worldwide,
Helicobacter pylori
is intensively associated with diverse gastric diseases, including gastric ulcers, chronic progressive gastritis, and gastric cancer. Aside from its pathogenic effect on gastric diseases, growing evidences reveal that
H. pylori
may be related to numerous extragastric diseases. In this article, we reviewed recent studies and systematically elucidated that
H. pylori
may interfere with many biological processes outside the stomach and influence the occurrence of various extragastric diseases. Many epidemiological studies have indicated that
H. pylori
plays a pathogenic role in COVID-19, atherosclerosis, hyperemesis gravidarum and several other extragastric diseases, while the effect of
H. pylori
is currently under investigation in gastroesophageal reflux disease, asthma, and inflammatory bowel disease. Moreover, we also summarized the possible pathogenic mechanisms of
H. pylori
that may be related to chronic systemic inflammation and molecular mimicker. Taken together, this review provides a new perspective on the role of
H. pylori
in extragastric diseases and explores the possible mechanisms, which may help guide clinical treatment. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Muhammad Shahid Riaz Rajoka, Tohoku University, Japan Reviewed by: A. K. M. Humayun Kober, Chittagong Veterinary and Animal Sciences University, Bangladesh; Ahmad Ud Din, Sichuan University, China These authors have contributed equally to this work This article was submitted to Microorganisms in Vertebrate Digestive Systems, a section of the journal Frontiers in Microbiology |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2022.972777 |