Regenerative Engineering: Current Applications and Future Perspectives

Many pathologies, congenital defects, and traumatic injuries are untreatable by conventional pharmacologic or surgical interventions. Regenerative engineering represents an ever-growing interdisciplinary field aimed at creating biological replacements for injured tissues and dysfunctional organs. Th...

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Published inFrontiers in surgery Vol. 8; p. 731031
Main Authors Goldenberg, Dana, McLaughlin, Caroline, Koduru, Srinivas V., Ravnic, Dino J.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 03.11.2021
Subjects
engineering
regeneration
Surgery
tissue dysfunction
transplantation
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Summary:Many pathologies, congenital defects, and traumatic injuries are untreatable by conventional pharmacologic or surgical interventions. Regenerative engineering represents an ever-growing interdisciplinary field aimed at creating biological replacements for injured tissues and dysfunctional organs. The need for bioengineered replacement parts is ubiquitous among all surgical disciplines. However, to date, clinical translation has been limited to thin, small, and/or acellular structures. Development of thicker tissues continues to be limited by vascularization and other impediments. Nevertheless, currently available materials, methods, and technologies serve as robust platforms for more complex tissue fabrication in the future. This review article highlights the current methodologies, clinical achievements, tenacious barriers, and future perspectives of regenerative engineering.
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This article was submitted to Reconstructive and Plastic Surgery, a section of the journal Frontiers in Surgery
Edited by: Lorenzo Cobianchi, University of Pavia, Italy
Reviewed by: Peter Dziewulski, St. Andrews Centre for Plastic Surgery and Burns, United Kingdom; Francesca Dal Mas, University of Lincoln, United Kingdom
ISSN:2296-875X
2296-875X
DOI:10.3389/fsurg.2021.731031