Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways

• Published in: Apoptosis (London) Vol. 28; no. 7-8; pp. 977 - 996
• Main Authors: Zhang, Ruijing, Bian, Che, Gao, Jing, Ren, Huiwen
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2023; Springer; Springer Nature B.V
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Biology; Cell culture; Chronic kidney failure; Complications and side effects; Diabetes; Diabetes mellitus; Diabetes Mellitus - pathology; Diabetic Nephropathies - genetics; Diabetic Nephropathies - pathology; Diabetic nephropathy; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Finite element method; Glomerulonephritis; Kidney - pathology; Kidney diseases; Kidneys; Metabolic disorders; Microvasculature; Oncology; Organelles; Protein folding; Proteins; Reabsorption; Reagents; Review; Type 2 diabetes; Unfolded Protein Response; Virology; Diabetes; Kidney; Endoplasmic reticulum stress; Diabetic kidney disease

Diabetes kidney disease (DKD) is one of the common chronic microvascular complications of diabetes, which has become the most important cause of modern chronic kidney disease beyond chronic glomerulonephritis. The endoplasmic reticulum is one of the largest organelles, and endoplasmic reticulum stre...