Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways

• Published in: Apoptosis (London) Vol. 28; no. 7-8; pp. 977 - 996
• Main Authors: Zhang, Ruijing, Bian, Che, Gao, Jing, Ren, Huiwen
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2023; Springer; Springer Nature B.V
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Biology; Cell culture; Chronic kidney failure; Complications and side effects; Diabetes; Diabetes mellitus; Diabetes Mellitus - pathology; Diabetic Nephropathies - genetics; Diabetic Nephropathies - pathology; Diabetic nephropathy; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Finite element method; Glomerulonephritis; Kidney - pathology; Kidney diseases; Kidneys; Metabolic disorders; Microvasculature; Oncology; Organelles; Protein folding; Proteins; Reabsorption; Reagents; Review; Type 2 diabetes; Unfolded Protein Response; Virology; Diabetes; Kidney; Endoplasmic reticulum stress; Diabetic kidney disease
• ISSN: 1360-8185; 1573-675X; 1573-675X
• DOI: 10.1007/s10495-023-01858-w

Diabetes kidney disease (DKD) is one of the common chronic microvascular complications of diabetes, which has become the most important cause of modern chronic kidney disease beyond chronic glomerulonephritis. The endoplasmic reticulum is one of the largest organelles, and endoplasmic reticulum stress (ERS) is the basic mechanism of metabolic disorder in all organs and tissues. Under the stimulation of stress-induced factors, the endoplasmic reticulum, as a trophic receptor, regulates adaptive and apoptotic ERS through molecular chaperones and three unfolded protein reaction (UPR) pathways, thereby regulating diabetic renal damage. Therefore, three pathway factors have different expressions in different sections of renal tissues. This study deeply discussed the specific reagents, animals, cells, and clinical models related to ERS in DKD, and reviewed ERS-related three pathways on DKD with glomerular filtration membrane, renal tubular reabsorption, and other pathological lesions of different renal tissues, as well as the molecular biological mechanisms related to the balance of adaption and apoptosis by searching and sorting out MeSH subject words from PubMed database.