Cerium Oxide/Polypyrrole Nanocomposite as the Matrix for Cholesterol Biosensor

A nanocomposite comprising cerium oxide nanoparticles (CeO2 NPs) and polypyrrole (PPy) was fabricated onto a microelectrode for cholesterol sensing application. The cholesterol oxidase (ChOx) was immobilized on the CeO2 NPs/PPy/electrode by the physical adsorption route. The structure and morphology...

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Published inAdvances in polymer technology Vol. 2021; pp. 1 - 10
Main Authors Anh, Ta Thi Nhat, Van Thu, Vu, Dang, Hai-Son, Pham, Vuong-Hung, Tam, Phuong Dinh
Format Journal Article
LanguageEnglish
Published Hindawi 04.02.2021
John Wiley & Sons, Inc
Wiley
Subjects
Adsorption
Cerium
Cholesterol
Detectors
Diffraction
Oxidases
X-rays
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Summary:A nanocomposite comprising cerium oxide nanoparticles (CeO2 NPs) and polypyrrole (PPy) was fabricated onto a microelectrode for cholesterol sensing application. The cholesterol oxidase (ChOx) was immobilized on the CeO2 NPs/PPy/electrode by the physical adsorption route. The structure and morphology of the CeO2 NPs/PPy nanocomposite were characterized by X-ray diffraction, field emission scanning electron microscopy, and energy dispersive X-ray spectroscopy. Results showed that the ChOx/CeO2 NPs/PPy/electrode was linearly related with cholesterol in the range of 50 to 500 mg/dL. The sensitivity of ChOx/CeO2 NPs/PPy/electrode was 5.7×10−6 mA/mg⋅dL−1. The optimal parameters, including pH value and temperature, and selectivity, storage stability, and reproducibility of ChOx/CeO2 NPs/PPy/electrode were investigated.
ISSN:0730-6679
1098-2329
DOI:10.1155/2021/6627645