Loss of Cep72 affects the morphology of spermatozoa in mice
The centrosome regulates mammalian meiosis by affecting recombination, synapsis, chromosome segregation, and spermiogenesis. Cep72 is one of the critical components of the centrosome. However, the physiological role of Cep72 in spermatogenesis and fertility remains unclear. In this study, we identif...
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Published in | Frontiers in physiology Vol. 13; p. 948965 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
07.10.2022
|
Subjects | |
Online Access | Get full text |
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Summary: | The centrosome regulates mammalian meiosis by affecting recombination, synapsis, chromosome segregation, and spermiogenesis. Cep72 is one of the critical components of the centrosome. However, the physiological role of Cep72 in spermatogenesis and fertility remains unclear. In this study, we identify Cep72 as a testis-specific expression protein. Although
Cep72
knockout mice were viable and fertile, their sperms were morphologically abnormal with incomplete flagellum structures. Transcriptome analysis reveals significant differences in six genes (
Gm49527
,
Hbb-bt
,
Hba-a2
,
Rps27a-ps2
,
Gm29647
, and
Gm8430
), which were not previously associated with spermatogenesis. Overall, these results indicate that Cep72 participates in regulating sperm morphology and yet is dispensable for fertility in mice. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work Jun Ma, University of Pennsylvania, United States Reviewed by: Jinmin Gao, Shandong Normal University, China Edited by: Wei Zheng, Reproductive and Genetic Hospital of CITIC-Xiangya, China This article was submitted to Reproduction, a section of the journal Frontiers in Physiology |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2022.948965 |