Four steroidal alkaloids from the leaves of Buxus sempervirens

• Published in: Phytochemistry (Oxford) Vol. 54; no. 8; pp. 951 - 957
• Main Authors: Loru, Fabrice, Duval, Danièle, Aumelas, André, Akeb, Fatima, Guédon, Didier, Guedj, Roger
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.08.2000; Elsevier
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Biochemistry & Molecular Biology; Biological and medical sciences; Boxwood; Buxaceae; Buxus sempervirens; Chemical constitution; Fundamental and applied biological sciences. Psychology; Life Sciences & Biomedicine; Magnoliopsida - chemistry; Molecular Structure; N 20-Acetylbuxamine E; N 20-Acetylbuxamine G; N 20-Formylbuxaminol E; O 16-Syringylbuxaminol E; Plant Leaves - chemistry; Plant physiology and development; Plant Sciences; Science & Technology; Spectrum Analysis; Steroidal alkaloids; Steroids - chemistry; Buxaceae; N 20-Acetylbuxamine E; Buxus sempervirens; N 20-Acetylbuxamine G; N 20-Formylbuxaminol E; Steroidal alkaloids; O 16-Syringylbuxaminol E; Boxwood; O-16-syringylbaxaminol E; N-20-formylbuxaminol E; NMR; SPECTROSCOPY; boxwood; N-20-acetylbuxamine E; steroidal alkaloids; N-20-acetylbuxamine G; Steroid; Alkaloid; Molecular structure; Dicotyledones; Angiospermae; Isolation; Spermatophyta; Plant leaf; Medicinal plant
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)00036-4

Four new steroidal alkaloids, N 20-formylbuxaminol E [(20S)-16α-hydroxy-20-(formylamino)-3β-(dimethylamino)-9,10-seco-buxa-9(11),10(19)-diene] ( 1), O 16-syringylbuxaminol E [(20S)-16α-syringoyl-3β-(dimethylamino)-20-(amino)-9,10-seco-buxa-9(11),10(19)-diene] ( 2), N 20-acetylbuxamine G [(20S)-20-(acetylamino)-3β-(methylamino)-9,10-seco-buxa-9(11),10(19)-diene] ( 3) and N 20-acetylbuxamine E [(20S)-20-(acetylamino)-3β-(dimethylamino)-9,10-seco-buxa-9(11),10(19)-diene] ( 4) were isolated from the leaves of Buxus sempervirens. Their structures were determined mainly on the basis of 2D NMR studies.