Role of microRNA alternation in the pathogenesis of gouty arthritis

Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3’ untranslated region (UTR) of mRNA and regulate the expressio...

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Published inFrontiers in endocrinology (Lausanne) Vol. 13; p. 967769
Main Authors Luo, Zhipan, Yang, Fan, Hong, Shaocheng, Wang, Jianpeng, Chen, Bangjie, Li, Liangyun, Yang, Junfa, Yao, Yan, Yang, Chenchen, Hu, Ying, Wang, Shuxian, Xu, Tao, Wu, Jun
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 11.08.2022
Subjects
biomarker
cellular signaling pathway
Endocrinology
gouty arthritis
hyperuricemia
MicroRNA
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Summary:Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3’ untranslated region (UTR) of mRNA and regulate the expression of a variety of proteins at the post-transcriptional level. In recent years, attention has been focused on the role of miRNAs in various inflammatory diseases, including gouty arthritis. It is thought that miRNAs may regulate immune function and inflammatory responses, thereby influencing the onset and progression of the disease. This article mainly reviewed the roles of miRNAs in the pathogenesis of gouty arthritis and prospected their potential as diagnostic and prognostic relevant biomarkers and as possible therapeutic targets.
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Reviewed by: Fengjie Sun, Georgia Gwinnett College, United States; Maojie Wang, Guangdong Provincial Hospital of Chinese Medicine, China
These authors have contributed equally to this work
Edited by: Isabelle Jéru, Assistance Publique Hopitaux De Paris, France
This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.967769