Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples
Ivabradine hydrochloride (IVR) is a medically important drug because of its ability to lower the heart rate. Techniques reported for IVR determination were expensive, laborious, besides being of poor selectivity. In this study, iron oxide @ carbon nanotube (Fe 2 O 3 @MWCNTs) nanocomposite and molecu...
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Published in | Frontiers in bioengineering and biotechnology Vol. 9; p. 648704 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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08.04.2021
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Abstract | Ivabradine hydrochloride (IVR) is a medically important drug because of its ability to lower the heart rate. Techniques reported for IVR determination were expensive, laborious, besides being of poor selectivity. In this study, iron oxide @ carbon nanotube (Fe
2
O
3
@MWCNTs) nanocomposite and molecularly imprinted polymer (MIP) were synthesized and used in the fabrication of carbon paste electrodes (CPEs) for the potentiometric detection of IVR in biological and pharmaceutical samples. CPEs of the best sensor were formulated from graphite (41 wt%) as a carbon source, MIP (3 wt.%) as an ionophore, Fe
2
O
3
@MWCNTs (5 wt%) as a modifier, and nitrophenyl octyl ether (NPOE, 51 wt.%) as a conductive oil so-called plasticizer. The best sensor exhibits a Nernstian slope (response) of 56 mV decade
–1
within the IVR concentration range from 1.0 × 10
–3
M to 9.8 × 10
–8
M with high selectivity against interfering species (ascorbic, maltose, glucose, lactose, dopamine, glycine) over those reported earlier. The use of Fe
2
O
3
@MWCNTs together with MIP in the electrode formulation was found to improve the limit of detection (LOD) from 630 to 98 nM along with high reversibility, a short response time of 30 s, and a good lifetime of more than 2 weeks. The sandwich membrane (SMM) method was used to quantify the H-bonding complexing strength of the MIP binding sites for IVR with Log β
ILn
= 11.33. The constructed sensors were successfully applied for the IVR determination in blood serum, urine, and commercial formulations (Savapran
®
) with high sensitivity. |
---|---|
AbstractList | Ivabradine hydrochloride (IVR) is a medically important drug because of its ability to lower the heart rate. Techniques reported for IVR determination were expensive, laborious, besides being of poor selectivity. In this study, iron oxide @ carbon nanotube (Fe
2
O
3
@MWCNTs) nanocomposite and molecularly imprinted polymer (MIP) were synthesized and used in the fabrication of carbon paste electrodes (CPEs) for the potentiometric detection of IVR in biological and pharmaceutical samples. CPEs of the best sensor were formulated from graphite (41 wt%) as a carbon source, MIP (3 wt.%) as an ionophore, Fe
2
O
3
@MWCNTs (5 wt%) as a modifier, and nitrophenyl octyl ether (NPOE, 51 wt.%) as a conductive oil so-called plasticizer. The best sensor exhibits a Nernstian slope (response) of 56 mV decade
–1
within the IVR concentration range from 1.0 × 10
–3
M to 9.8 × 10
–8
M with high selectivity against interfering species (ascorbic, maltose, glucose, lactose, dopamine, glycine) over those reported earlier. The use of Fe
2
O
3
@MWCNTs together with MIP in the electrode formulation was found to improve the limit of detection (LOD) from 630 to 98 nM along with high reversibility, a short response time of 30 s, and a good lifetime of more than 2 weeks. The sandwich membrane (SMM) method was used to quantify the H-bonding complexing strength of the MIP binding sites for IVR with Log β
ILn
= 11.33. The constructed sensors were successfully applied for the IVR determination in blood serum, urine, and commercial formulations (Savapran
®
) with high sensitivity. Ivabradine hydrochloride (IVR) is a medically important drug because of its ability to lower the heart rate. Techniques reported for IVR determination were expensive, laborious, besides being of poor selectivity. In this study, iron oxide @ carbon nanotube (Fe2O3@MWCNTs) nanocomposite and molecularly imprinted polymer (MIP) were synthesized and used in the fabrication of carbon paste electrodes (CPEs) for the potentiometric detection of IVR in biological and pharmaceutical samples. CPEs of the best sensor were formulated from graphite (41 wt%) as a carbon source, MIP (3 wt.%) as an ionophore, Fe2O3@MWCNTs (5 wt%) as a modifier, and nitrophenyl octyl ether (NPOE, 51 wt.%) as a conductive oil so-called plasticizer. The best sensor exhibits a Nernstian slope (response) of 56 mV decade–1 within the IVR concentration range from 1.0 × 10–3 M to 9.8 × 10–8 M with high selectivity against interfering species (ascorbic, maltose, glucose, lactose, dopamine, glycine) over those reported earlier. The use of Fe2O3@MWCNTs together with MIP in the electrode formulation was found to improve the limit of detection (LOD) from 630 to 98 nM along with high reversibility, a short response time of 30 s, and a good lifetime of more than 2 weeks. The sandwich membrane (SMM) method was used to quantify the H-bonding complexing strength of the MIP binding sites for IVR with Log βILn = 11.33. The constructed sensors were successfully applied for the IVR determination in blood serum, urine, and commercial formulations (Savapran®) with high sensitivity. |
Author | Madbouly, Adel Elnabawy, Hussam M. El Nashar, Rasha M. Khalil, Ahmed S. G. Anis, Badawi Gamal, Eman Barhoum, Ahmed Rizk, Mahmoud S. Abdel-Haleem, Fatehy M. |
AuthorAffiliation | 4 Environmental and Smart Technology Group (ESTG), Faculty of Science, Fayoum University , Faiyum , Egypt 6 NanoStruc. Research Group, Chemistry Department, Faculty of Science, Helwan University , Cairo , Egypt 1 Chemistry Department, Faculty of Science, Cairo University , Giza , Egypt 3 Spectroscopy Department, National Research Centre , Giza , Egypt 5 Materials Science and Engineering Department, School of Innovative Design Engineering, Egypt-Japan University of Science and Technology (E-JUST) , New Borg El-Arab City , Egypt 2 Cairo University Centre for Environmental Hazards Mitigation, Environmental Studies and Research, CHMESR, Cairo University , Giza , Egypt 7 National Centre for Sensor Research, School of Chemical Sciences, Dublin City University , Dublin , Ireland |
AuthorAffiliation_xml | – name: 2 Cairo University Centre for Environmental Hazards Mitigation, Environmental Studies and Research, CHMESR, Cairo University , Giza , Egypt – name: 6 NanoStruc. Research Group, Chemistry Department, Faculty of Science, Helwan University , Cairo , Egypt – name: 7 National Centre for Sensor Research, School of Chemical Sciences, Dublin City University , Dublin , Ireland – name: 5 Materials Science and Engineering Department, School of Innovative Design Engineering, Egypt-Japan University of Science and Technology (E-JUST) , New Borg El-Arab City , Egypt – name: 1 Chemistry Department, Faculty of Science, Cairo University , Giza , Egypt – name: 4 Environmental and Smart Technology Group (ESTG), Faculty of Science, Fayoum University , Faiyum , Egypt – name: 3 Spectroscopy Department, National Research Centre , Giza , Egypt |
Author_xml | – sequence: 1 givenname: Fatehy M. surname: Abdel-Haleem fullname: Abdel-Haleem, Fatehy M. – sequence: 2 givenname: Eman surname: Gamal fullname: Gamal, Eman – sequence: 3 givenname: Mahmoud S. surname: Rizk fullname: Rizk, Mahmoud S. – sequence: 4 givenname: Adel surname: Madbouly fullname: Madbouly, Adel – sequence: 5 givenname: Rasha M. surname: El Nashar fullname: El Nashar, Rasha M. – sequence: 6 givenname: Badawi surname: Anis fullname: Anis, Badawi – sequence: 7 givenname: Hussam M. surname: Elnabawy fullname: Elnabawy, Hussam M. – sequence: 8 givenname: Ahmed S. G. surname: Khalil fullname: Khalil, Ahmed S. G. – sequence: 9 givenname: Ahmed surname: Barhoum fullname: Barhoum, Ahmed |
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ContentType | Journal Article |
Copyright | Copyright © 2021 Abdel-Haleem, Gamal, Rizk, Madbouly, El Nashar, Anis, Elnabawy, Khalil and Barhoum. 2021 Abdel-Haleem, Gamal, Rizk, Madbouly, El Nashar, Anis, Elnabawy, Khalil and Barhoum |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Pramod K. Kalambate, Chulalongkorn University, Thailand; Omer Sadak, Ardahan University, Turkey; Anu Prathap, PEC University of Technology, India Edited by: Anandhakumar Sundaramurthy, SRM Institute of Science and Technology, India This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology |
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Title | Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples |
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