Therapeutic targets by traditional Chinese medicine for ischemia-reperfusion injury induced apoptosis on cardiovascular and cerebrovascular diseases

Traditional Chinese medicine (TCM) has a significant role in treating and preventing human diseases. Ischemic heart and cerebrovascular injuries are two types of diseases with different clinical manifestations with high prevalence and incidence. In recent years, it has been reported that many TCM ha...

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Published inFrontiers in pharmacology Vol. 13; p. 934256
Main Authors Cheng, Xiuli, Hu, Jin, Liu, Xiaofeng, Tibenda, Jonnea Japhet, Wang, Xiaobo, Zhao, Qipeng
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 19.08.2022
Subjects
apoptosis
cerebral ischemia
molecular mechanisms
myocardial ischemia
Pharmacology
traditional Chinese medicine
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Summary:Traditional Chinese medicine (TCM) has a significant role in treating and preventing human diseases. Ischemic heart and cerebrovascular injuries are two types of diseases with different clinical manifestations with high prevalence and incidence. In recent years, it has been reported that many TCM has beneficial effects on ischemic diseases through the inhibition of apoptosis, which is the key target to treat myocardial and cerebral ischemia. This review provides a comprehensive summary of the mechanisms of various TCMs in treating ischemic cardiovascular and cerebrovascular diseases through anti-apoptotic targets and pathways. However, clinical investigations into elucidating the pharmacodynamic ingredients of TCM are still lacking, which should be further demystified in the future. Overall, the inhibition of apoptosis by TCM may be an effective strategy for treating ischemic cardio-cerebrovascular diseases.
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This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Edited by: Narasimham L. Parinandi, The Ohio State University, United States
These authors have contributed equally to this work
Reviewed by: Pilli Govindaiah, Lovely Professional University, India
Sanjay Varikuti, The Ohio State University, United States
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.934256