The gamble between oncolytic virus therapy and IFN

Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very...

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Published inFrontiers in immunology Vol. 13; p. 971674
Main Authors Li, Qingbo, Tan, Fengxian, Wang, Yuanyuan, Liu, Xiaohui, Kong, Xianbin, Meng, Jingyan, Yang, Long, Cen, Shan
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 25.08.2022
Subjects
cancer
IFN
Immunology
oncology
oncolytic virus
signaling
tumor
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Summary:Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.
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These authors have contributed equally to this work
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
Edited by: Jieying Bai, Academy of Military Medical Sciences (AMMS), China
Reviewed by: Wenyan Zhang, First Affiliated Hospital of Jilin University, China; Guoli Shi, National Institutes of Health (NIH), United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.971674