Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide

• Published in: Hepatology international Vol. 9; no. 2; pp. 258 - 268
• Main Authors: Liang, Po-Chin, Ch’ang, Hui-Ju, Hsu, Chiun, Chen, Li-Tzong, Shih, Tiffany T. F., Liu, Tsang Wu
• Format: Journal Article
• Language: English
• Published: India Springer India 01.04.2015; Springer Nature B.V
• Subjects: Aged; Angiogenesis Inhibitors - therapeutic use; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - radiotherapy; Colorectal Surgery; Combined Modality Therapy - methods; Contrast Media; Disease-Free Survival; Female; Gadolinium DTPA; Hepatology; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - radiotherapy; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Original Article; Signal Processing, Computer-Assisted; Surgery; Survival Rate; Thalidomide - therapeutic use; Treatment Outcome; Dynamic contrast-enhanced MRI; Hepatocellular carcinoma; Radiotherapy; Thalidomide; Antiangiogenesis
• ISSN: 1936-0533; 1936-0541
• DOI: 10.1007/s12072-014-9557-1

Background To correlate between signal parameters using dynamic contrast-enhanced magnetic resonance imaging (DCEMRI) and outcomes of hepatocellular carcinoma (HCC) receiving radiotherapy with or without concomitant thalidomide. Methods DCEMRI was performed in advanced HCC patients undergoing radiotherapy with or without concomitant thalidomide. Initial first-pass enhancement slopes (slope) and peak enhancement ratios (peak) were measured over an operator-defined region of interest over tumor and non-tumor liver parenchyma. The perfusion parameters were correlated with clinical outcomes. The study was registered with ClinicalTrials.gov. (identifier NCT00155272). Results Forty-three patients were evaluable. There were 18 partial responses (PRs), 5 minimal responses (MRs), 17 stable diseases (SDs), and 3 progressive diseases (PDs). Baseline perfusion parameters as well as slope at 14 days of radiotherapy were higher in patients with PR or MR compared to SD or PD (0.81 ± 0.29 vs. 0.49 ± 0.34, p  < 0.01; 0.39 ± 0.15 vs. 0.28 ± 0.16, p  = 0.02; 0.97 ± 0.38 vs. 0.46 ± 0.26, p  < 0.01; respectively). Multivariate analysis revealed perfusion parameters over liver parenchyma, but not over tumor, and independently predicted progression-free and overall survival (182 ± 33 vs. 105 ± 26 days, p  = 0.01; 397 ± 111 vs. 233 ± 19 days, p  = 0.001 respectively). For 22 patients receiving concomitant thalidomide, the perfusion parameters were not significantly different from those receiving radiotherapy alone. Conclusions Signal parameters of DCEMRI over tumor and liver parenchyma correlated with tumor response and survival, respectively, in HCC patients receiving radiotherapy.