Atrial cardiopathy and cognitive impairment

Cognitive impairment involves complex interactions between multiple pathways and mechanisms, one of which being cardiac disorders. Atrial cardiopathy (AC) is a structural and functional disorder of the left atrium that may be a substrate for other cardiac disorders such as atrial fibrillation (AF) a...

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Published inFrontiers in aging neuroscience Vol. 14; p. 914360
Main Authors Myers, Sarah J., Jiménez-Ruiz, Amado, Sposato, Luciano A., Whitehead, Shawn N.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.07.2022
Subjects
atrial cardiopathy
atrial fibrillation
cognitive impairment
dementia
heart failure
Neuroscience
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Summary:Cognitive impairment involves complex interactions between multiple pathways and mechanisms, one of which being cardiac disorders. Atrial cardiopathy (AC) is a structural and functional disorder of the left atrium that may be a substrate for other cardiac disorders such as atrial fibrillation (AF) and heart failure (HF). The association between AF and HF and cognitive decline is clear; however, the relationship between AC and cognition requires further investigation. Studies have shown that several markers of AC, such as increased brain natriuretic peptide and left atrial enlargement, are associated with an increased risk for cognitive impairment. The pathophysiology of cognitive decline in patients with AC is not yet well understood. Advancing our understanding of the relationship between AC and cognition may point to important treatable targets and inform future therapeutic advancements. This review presents our current understanding of the diagnosis of AC, as well as clinical characteristics and potential pathways involved in the association between AC and cognitive impairment.
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Reviewed by: Neil Bodagh, Kingston Hospital, United Kingdom; Vida Demarin, International Institute for Brain Health, Croatia; Andriy Yabluchanskiy, The University of Oklahoma Health Sciences Center, United States
This article was submitted to Cellular and Molecular Mechanisms of Brain-aging, a section of the journal Frontiers in Aging Neuroscience
Edited by: Ivana Hollan, Norwegian University of Science and Technology, Norway
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.914360