Nanomechanical Properties of Selected Single Pharmaceutical Crystals as a Predictor of Their Bulk Behaviour
Purpose The main goal of this research was to assess the mechanical properties of APIs’ polymorphic forms at the single-crystal level (piroxicam, famotidine, nifedipine, olanzapine) in order to predict their bulk deformational attributes, which are critical for some pharmaceutical technology process...
Saved in:
Published in | Pharmaceutical research Vol. 32; no. 2; pp. 469 - 481 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.02.2015
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Purpose
The main goal of this research was to assess the mechanical properties of APIs’ polymorphic forms at the single-crystal level (piroxicam, famotidine, nifedipine, olanzapine) in order to predict their bulk deformational attributes, which are critical for some pharmaceutical technology processes.
Methods
The mechanical properties of oriented single crystals were determined using instrumented nanoindentation (continuous stiffness measurement). All polymorphic forms investigated were previously identified using a combination of calorimetric and spectroscopic techniques.
Results
Mechanical properties such as Young’s modulus and indentation hardness were consistent with the molecular packing of the polymorphic forms investigated with respect to crystal orientation. For mechanically interlocked structures, characteristic of most polymorphic forms, response of single crystals to indentation was isotropic. The material’s bulk elastic properties can be successfully predicted by measuring Young’s modulus of single crystals because a good linear correlation with a bulk parameter such as the tablets’ elastic relaxation index was determined.
Conclusions
The results confirm the idea that the intrinsic mechanical properties of pharmaceutical crystals (Young’s modulus) largely control and anticipate their deformational behavior during tablet compression. Young’s modulus and indentation hardness represent a very valuable and effective tool in preformulation studies for describing materials’ mechanical attributes, which are important for technological processes in which materials are exposed to deformation. |
---|---|
ISSN: | 0724-8741 1573-904X |
DOI: | 10.1007/s11095-014-1475-3 |