Catalyst free, three-component approach for unsymmetrical triarylmethanes (TRAMs)

[Display omitted] This manuscript describes the first catalyst free, three component approach to triarylmethanes. •First acid and transition metal free strategy to TRAMS.•Simple thermal conditions and highly efficient.•Three-component, tandem approach.•Very broad substrate scope. An efficient cataly...

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Bibliographic Details
Published inTetrahedron letters Vol. 57; no. 48; pp. 5381 - 5384
Main Authors Chinta, Bhavani Shankar, Baire, Beeraiah
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 30.11.2016
Elsevier
Subjects
Cascade strategy
Catalyst free
Chemistry
Chemistry, Organic
Grignard reagents
Physical Sciences
Science & Technology
Three-component
Triarylmethanes
Grignard reagents
Three-component
Cascade strategy
Catalyst free
Triarylmethanes
DESIGN
ONE-POT SYNTHESIS
FRIEDEL-CRAFTS REACTIONS
ARYLBORONIC ACIDS
CROSS-COUPLINGS
SEQUENTIAL ARYLATION
IN-VIVO
CHEMISTRY
ARYL
K+ CHANNEL
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Summary:[Display omitted] This manuscript describes the first catalyst free, three component approach to triarylmethanes. •First acid and transition metal free strategy to TRAMS.•Simple thermal conditions and highly efficient.•Three-component, tandem approach.•Very broad substrate scope. An efficient catalyst free, three-component, cascade approach has been designed and developed for the rapid assembly of unsymmetrical triarylmethane framework. The strategy employed aromatic aldehydes, Grignard reagents, and neutral aromatics as reaction partners, under simple thermal conditions. This process affords very broad scope for all three partners as it is performed in the absence of any external additives.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.10.087