Detection of vapor-phase organophosphate threats using wearable conformable integrated epidermal and textile wireless biosensor systems

• Published in: Biosensors & bioelectronics Vol. 101; pp. 227 - 234
• Main Authors: Mishra, Rupesh K., Martín, Aida, Nakagawa, Tatsuo, Barfidokht, Abbas, Lu, Xialong, Sempionatto, Juliane R., Lyu, Kay Mengjia, Karajic, Aleksandar, Musameh, Mustafa M., Kyratzis, Ilias L., Wang, Joseph
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.03.2018
• Subjects: air; Air - analysis; aryldialkylphosphatase; Aryldialkylphosphatase - chemistry; Biosensing Techniques - instrumentation; biosensors; deformation; Electrodes; Equipment Design; fabrics; Humans; Integrated flexible electronics; Limit of Detection; Nerve agent; nerve agents; Nerve Agents - analysis; OPH-biosensor; Organophosphate; Organophosphorus Compounds - analysis; Reproducibility of Results; Textiles; Vapor phase detection; vapors; Volatilization; Wearable Electronic Devices; Wearable sensor; Wireless Technology - instrumentation; Integrated flexible electronics; OPH-biosensor; Wearable sensor; Organophosphate; Vapor phase detection; Nerve agent
• ISSN: 0956-5663; 1873-4235; 1873-4235
• DOI: 10.1016/j.bios.2017.10.044

Flexible epidermal tattoo and textile-based electrochemical biosensors have been developed for vapor-phase detection of organophosphorus (OP) nerve agents. These new wearable sensors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are coupled with a fully integrated conformal flexible electronic interface that offers rapid and selective square-wave voltammetric detection of OP vapor threats and wireless data transmission to a mobile device. The epidermal tattoo and textile sensors display a good reproducibility (with RSD of 2.5% and 4.2%, respectively), along with good discrimination against potential interferences and linearity over the 90–300mg/L range, with a sensitivity of 10.7µA∙cm3∙mg−1 (R2 = 0.983) and detection limit of 12mg/L in terms of OP air density. Stress-enduring inks, used for printing the electrode transducers, ensure resilience against mechanical deformations associated with textile and skin-based on-body sensing operations. Theoretical simulations are used to estimate the OP air density over the sensor surface. These fully integrated wearable wireless tattoo and textile-based nerve-agent vapor biosensor systems offer considerable promise for rapid warning regarding personal exposure to OP nerve-agent vapors in variety of decentralized security applications. Wearable Conformable Integrated Epidermal and Textile Wireless Biosensor Systems for vapor-phase detection of nerve-agent threats. [Display omitted] •Wearable epidermal Tattoo and textile biosensor for OP vapor detection.•Simple method to nebulize OP.•Smallest flexible square wave voltammetry-based electronic board.•Wireless data transmission for wearable electronics.