Metal deposition and functional neurotoxicity in rats after 3–6 weeks nasal exposure by two physicochemical forms of manganese

Abstract Airborne manganese represents a major risk of nervous system damage first of all in industrial settings. The resulting effects may depend on the dose and physicochemical form of Mn. To compare the effect of soluble and nanoparticulate Mn, adult male rats received daily instillation of MnCl2...

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Published inEnvironmental toxicology and pharmacology Vol. 30; no. 2; pp. 121 - 126
Main Authors Oszlánczi, Gábor, Vezér, Tünde, Sárközi, Leila, Horváth, Edina, Szabó, Andrea, Horváth, Endre, Kónya, Zoltán, Papp, András
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2010
Subjects
Electrocorticogram
Emergency
Evoked potentials
Intranasal application
Manganese
Nanoparticles
Neurotoxicity
Open field
Rat
SS
electrocorticogram
VIS
compound action potential
NP
Rat
nanoparticle
EP
Open field
Intranasal application
AUD
Nanoparticles
evoked potential
somatosensory
Neurotoxicity
CAP
Evoked potentials
auditory
ECoG
visual
Manganese
Electrocorticogram
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Summary:Abstract Airborne manganese represents a major risk of nervous system damage first of all in industrial settings. The resulting effects may depend on the dose and physicochemical form of Mn. To compare the effect of soluble and nanoparticulate Mn, adult male rats received daily instillation of MnCl2 solution or MnO2 nanoparticle suspension (dose: 2.53 mg Mn per rat) into the nasal cavity for 3 and 6 weeks. At the end of treatment, spontaneous open field motility was tested, electrophysiological recording was done in anesthesia, and brain tissue Mn level was determined. Metal level increase in the rats’ brain, body weight gain reduction, and decrease of open field motility was significant in the MnCl2 , but not nano-Mn, treated rats. Most evoked cortical activity parameters were significantly altered in both groups, but spontaneous cortical activity spectrum only in the rats receiving MnCl2 . There was fair correlation between brain Mn levels and certain neuro-functional parameters, underlining the causal relationship. Electrophysiological tests might be more sensitive to the effects of Mn than general toxicological or neurobehavioral tests.
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ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2010.04.006