Effects of early life stress during stress hyporesponsive period (SHRP) on anxiety and curiosity in adolescent rats

• Published in: Experimental brain research Vol. 240; no. 4; pp. 1127 - 1138
• Main Authors: Sharma, Shruthi S., Srinivas Bharath, M. M., Doreswamy, Yoganarasimha, Laxmi, T. Rao
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer; Springer Nature B.V
• Subjects: Adolescents; Adverse Childhood Experiences; Animal models; Animals; Anxiety; Anxiety - etiology; Anxiety - psychology; Anxiety Disorders; Anxiety in children; Biomedical and Life Sciences; Biomedicine; Child development; Cognitive ability; Corticosterone; Curiosity; Dopamine; Emotional behavior; Exploratory Behavior; Health aspects; Humans; Maternal Deprivation; Neurology; Neurosciences; Patient outcomes; Psychological aspects; Rats; Rats, Sprague-Dawley; Research Article; Social aspects; Stress in children; Stress, Psychological - psychology; Teenagers; India; Early life stress; Anxiety; Dopamine; Corticosterone; Curiosity; Intrinsic drive
• ISSN: 0014-4819; 1432-1106
• DOI: 10.1007/s00221-022-06319-5

Repeated exposure to adverse experiences in early life, termed Early Life Stress (ELS), can increase anxiety disorders later in life. Anxiety is directly associated with curiosity, a form of intrinsic drive state associated with increased novelty-seeking behaviour and risk taking for challenging opportunities and could probably modulate learning and memory. In humans, elevated curiosity during adolescence tends to elicit increased exploration, novelty seeking, high risk-taking behaviour and heightened emotionality. Such behaviours are beneficial in maintaining social skills and cognitive functions later in life. We investigated whether ELS-induced anxiety impacts curiosity-like behaviour at adolescence in an animal model. ELS was induced by subjecting Sprague Dawley rat pups to maternal separation and isolation (MS) stress during the stress hyporesponsive period (SHRP) from post-natal days (PND) 4-PND 14. This rat model was tested for anxiety, spontaneous exploratory behaviour and curiosity-like behaviour in a custom-designed arena during adolescence (PND 30–45). ELS-induced changes in the stress were confirmed by corticosterone, while, basal dopamine level was estimated to understand the neurochemical basis of MS stress-induced changes in curiosity. We observed an increase in the levels of anxiety and intrinsic drive state such as curiosity-like behaviour, which was associated with elevated plasma corticosterone and dopamine in MS animals during adolescence suggesting the impact of ELS during SHRP on adolescent behaviour.