Thiamine Attenuates Hypoxia-induced Cell Death in Cultured Neonatal Rat Cardiomyocytes

Previous studies have demonstrated that thiamine (vitamin B1) has a cytoprotective effect against ischemic damage to the heart, and that heat shock protein 70 (Hsp70) is capable of protecting cardiac cells from lethal ischemia/hypoxia.

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Bibliographic Details
Published inMolecules and cells Vol. 18; no. 2; pp. 133 - 140
Main Authors Shin, B.H, Cho, E.Y, Shin, M.J, Hwang, K.C, Cho, H.K, Chung J.H, Jang, Y.S. (Yonsei University College of Medicine, Seoul, Republic of Korea), Choi, S.H. (Hallym University College of Medicine, Seoul, Republic of Korea)
Format Journal Article
LanguageEnglish
Published United States 31.10.2004
Subjects
AGING
Animals
Animals, Newborn
Apoptosis - drug effects
Caspase 3
Caspases - metabolism
Cells, Cultured
DNA Fragmentation
HEAT SHOCK PROTEINS
HSP70 Heat-Shock Proteins - physiology
Hypoxia - pathology
Myocytes, Cardiac - drug effects
Poly(ADP-ribose) Polymerases - metabolism
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
Thiamine - pharmacology
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Summary:Previous studies have demonstrated that thiamine (vitamin B1) has a cytoprotective effect against ischemic damage to the heart, and that heat shock protein 70 (Hsp70) is capable of protecting cardiac cells from lethal ischemia/hypoxia.
Bibliography:2004008464
L01
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1016-8478
DOI:10.1016/s1016-8478(23)13093-7