Renal functions in obstructive sleep apnea patients

• Published in: Sleep & breathing Vol. 20; no. 1; pp. 191 - 195
• Main Authors: Uyar, Meral, Davutoğlu, Vedat, Gündoğdu, Nevhiz, Kosovalı, Deniz, Sarı, İbrahim
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016; Springer Nature B.V
• Subjects: Adult; Aged; Creatinine - blood; Dentistry; Female; Glomerular Filtration Rate - physiology; Humans; Hypertension; Hypertension - diagnosis; Hypertension - physiopathology; Hypertrophy, Left Ventricular - diagnosis; Hypertrophy, Left Ventricular - physiopathology; Internal Medicine; Kidney diseases; Male; Medicine; Medicine & Public Health; Metabolic Syndrome - diagnosis; Metabolic Syndrome - physiopathology; Middle Aged; Neurology; Original Article; Otorhinolaryngology; Pediatrics; Pneumology/Respiratory System; Polysomnography; Reference Values; Retrospective Studies; Sex Factors; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - physiopathology; Turkey; GFR; Gender; Metabolic syndrome; Sleep-disordered breathing; Left ventricular hypertrophy
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-015-1204-0

Purpose The aim of this study is to investigate possible factors influencing glomerular filtration rate (GFR) in obstructive sleep apnea (OSA). Methods Data of OSA patients admitted to Gaziantep University sleep clinic from January 2005 to January 2010 were retrospectively evaluated. GFR is calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Patients younger than 18 years old were excluded. Results The mean age of OSA ( n  = 634) and control group ( n  = 62) were 51.13 ± 11.61 and 50.69 ± 13.88 years, respectively ( p  = 0.81). The mean estimated GFR (eGFR) was 90.73 ± 19.59 ml/min/1.73 m 2 in OSA patients and 94.14 ± 18.81 ml/min/1.73 m 2 in control subjects ( p  = 0.19). GFR was 84.25 ± 20.87 ml/min/1.73 m 2 in patients with left ventricular hypertrophy (LVH) while it was 93.94 ± 18.44 ml/min/1.73 m 2 in patients without LVH ( p  = 0.00). GFR of male subjects was 92.1 ± 19.23 in OSA and 95.84 ± 20.08 ml/min/1.73 m 2 in controls ( p  = 0.33). GFR of female and male patients in the OSA were 87.45 ± 20.10 and 92.91 ± 18.02 ml/min/1.73 m 2 , respectively ( p  = 0.13). Serum creatinine was higher in OSA patients compared to controls ( p  = 0.01). GFR was 92.30 ± 19.27 in male and 88.33 ± 19.84 ml/min/1.73 m 2 in female subjects ( p  = 0.01). GFR was 84.86 ± 19.95 in hypertensive patients while it was 95.11 ± 18.20 ml/min/1.73 m 2 in normotensive subjects ( p  = 0.00). GFR was 89.30 ± 19.96 in patients with metabolic syndrome (MetS) and it was 93.46 ± 18.68 ml/min/1.73 m 2 in patients without MetS ( p  = 0.00). Conclusions GFR values were lower in sleep apneic patients with MetS as well as in patients with hypertension and LVH.