Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group

• Published in: International journal of hematology Vol. 112; no. 3; pp. 409 - 417
• Main Authors: Kimura, Shun-ichi, Fujita, Hiroyuki, Handa, Hiroshi, Hiramoto, Nobuhiro, Hosono, Naoko, Minamiguchi, Hitoshi, Takahashi, Tsutomu, Kato, Hideaki, Ono, Takaaki, Kanda, Yoshinobu, Kiyoi, Hitoshi, Matsumura, Itaru, Miyazaki, Yasushi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2020; Springer Nature B.V
• Subjects: Acute myeloid leukemia; Amides; Antibiotics; Antifungal agents; Antiinfectives and antibacterials; Antimicrobial agents; Chemotherapy; Colony-stimulating factor; Diagnostic systems; Fluoroquinolones; Fungicides; Hematology; Infections; Infectious diseases; Influenza; Institutions; Leukemia; Leukocytes (granulocytic); Management; Medicine; Medicine & Public Health; Myeloid leukemia; Neutropenia; Oncology; Original Article; Polls & surveys; Prophylaxis; Questionnaires; Questions; β-Lactam antibiotics; Japan; Acute leukemia; Antifungal therapy; Antimicrobial stewardship; Antibiotic therapy; Febrile neutropenia
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-020-02921-x

We conducted a nationwide questionnaire-based survey in 2019 following 2001, 2007 and 2013 surveys to clarify the real-world management of infection during chemotherapy for acute leukemia in Japan. An online questionnaire was sent through SurveyMonkey ® to member institutions of the Japan Adult Leukemia Study Group in June 2019. The questionnaire consisted of 52 multiple-choice questions covering prophylactic measures, screening and diagnostic tests, empirical antibiotic therapy, antifungal management, the usage of granulocyte-colony stimulating factor, and vaccinations against influenza and pneumococcus during intensive chemotherapy for acute leukemia. Questions associated with antimicrobial stewardship were also included. Usable responses were received from 163 of 218 (74.8%) institutions. Approximately, half (52.2%) of the institutes did not have infectious disease department. As antibiotic prophylaxis, fluoroquinolones (62%) were most commonly used in induction chemotherapy for acute myeloid leukemia. No prophylaxis accounted for 19% of the institutions, which has gradually increased compared to previous surveys. In empirical antibiotic therapy for febrile neutropenia, monotherapy with β-lactam antibiotics was the most commonly used first-line therapy. De-escalation was not considered in 42.2% of the institutions. In conclusion, this study clarified the real-world management of infection during intensive chemotherapy for acute leukemia in 2019 and raised future issues in Japan.