Fine Needle Aspiration Cytology Implementation and Malignancy Rates in Children and Adolescents Based on Japanese Guidelines: The Fukushima Health Management Survey

• Published in: Thyroid (New York, N.Y.) Vol. 31; no. 11; pp. 1683 - 1692
• Main Authors: Shimura, Hiroki, Matsuzuka, Takashi, Suzuki, Satoru, Iwadate, Manabu, Suzuki, Satoshi, Yokoya, Susumu, Ohira, Tetsuya, Yasumura, Seiji, Suzuki, Shinichi, Ohto, Hitoshi, Kamiya, Kenji
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc., publishers 01.11.2021
• Subjects: Adolescent; Biopsy, Fine-Needle; Child; Child, Preschool; Cytodiagnosis - methods; Female; Fukushima Nuclear Accident; Health Surveys; Humans; Infant; Infant, Newborn; Japan - epidemiology; Male; Thyroid Cancer and Nodules; Thyroid Neoplasms - diagnostic imaging; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - etiology; Thyroid Neoplasms - pathology; Thyroid Nodule - diagnostic imaging; Thyroid Nodule - epidemiology; Thyroid Nodule - etiology; Thyroid Nodule - pathology; Ultrasonography; Japan; Fukushima; thyroid cancer; children; ultrasonography; fine needle aspiration cytology
• ISSN: 1050-7256; 1557-9077
• DOI: 10.1089/thy.2021.0072

Background: The thyroid ultrasound examination (TUE) program was initiated among the residents of Fukushima Prefecture aged ≤18 years at the time of the Fukushima Dai-ichi Nuclear Power Plant accident. In this program, fine needle aspiration cytology (FNAC) was performed only in cases that conformed to the Japanese guidelines for the management of thyroid nodules. To analyze the suitability of the protocol in the TUE, we analyzed the implementation rate of FNAC and the detection rate of thyroid malignancy. Methods: There were 299,939 and 269,659 voluntary participants in the Preliminarily Baseline Survey (PLBS), first-round survey, and the first Full-scale Survey (FSS), second-round survey, of the TUE, respectively. FNAC is recommended for nodules with diameters 5.1–10.0 mm showing sonographic characteristics that are strongly suspicious for thyroid carcinoma; diameters 10.1–20.0 mm with characteristics that are suspicious for carcinoma; and all nodules with diameters >20 mm. Results: In the PLBS and the first FSS, 1362 and 1382 cases with thyroid nodules sized ≥5.1 mm in diameter were found, respectively. The implementation rates of FNAC in the PLBS were 20.1%, 63.2%, and 87.7% of subjects with nodules sized 5.1–10.0, 10.1–20.0, and ≥20.1 mm in diameter, respectively. In the first FSS, the FNAC implementation rates were 7.3%, 26.0%, and 50.0% in the subjects with nodules with diameters 5.1–10.0, 10.1–20.0, and ≥20.1 mm, respectively. In the subjects who underwent FNAC, the detection rates of malignant and suspected malignant nodules were 21.4% and 34.1% in the PLBS and first FSS, respectively. In the first FSS, malignant or suspected malignant nodules were found in 0.63% and 0.40% of subjects who had nodules of diameters ≤5.0 mm and 5.1–10.0 mm in the PLBS, respectively. In contrast, in the subjects with nodules measuring ≥10.0 mm in diameter in the PLBS, no malignancies were detected. Conclusions: The use of a protocol that conformed to the Japanese guidelines led to a reduction in the FNAC implementation rate and an increase in the malignancy detection rate in smaller nodules. In addition, the use of this strategy enabled us to avoid detection failure of thyroid carcinomas >10.0 mm.