A population-based study of progression to metastatic prostate cancer in Australia

• Published in: Cancer epidemiology Vol. 39; no. 4; pp. 617 - 622
• Main Authors: Luo, Qingwei, Yu, Xue Qin, Smith, David Paul, O’Connell, Dianne Lesley
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2015; Elsevier Limited
• Subjects: Aged; Australia; Breast cancer; Cancer; Cancer registry; Disease Progression; Distant metastases; Epidemiology; Geographical disparity; Geographical location; Hematology, Oncology and Palliative Medicine; Humans; Internal Medicine; Lymphatic system; Male; Men; Mens health; Metastasis; Middle Aged; Neoplasm Metastasis; Population; Population-based study; Proportional Hazards Models; Prostate cancer; Prostatic Neoplasms - pathology; Socio-economic status; Stage at diagnosis; Australia; SES; Index of Relative Socio-economic Disadvantage; New South Wales; Distant metastases; local government area; HR; ASGC; Central Cancer Registry; socio-economic status; IRSD; Geographical location; age-standardised incidence rate; PSA; ASR; CI; Geographical disparity; LGA; Disease progression; Stage at diagnosis; Australian Standard Geographic Classification; NSW; CCR; Cancer registry; hazard ratio; Population-based study; confidence interval; Prostate cancer; prostate-specific antigen; Socio-economic status
• ISSN: 1877-7821; 1877-783X
• DOI: 10.1016/j.canep.2015.04.013

Highlights • The first population-based study to examine the patterns of metastatic prostate cancer disease progression. • Overall, 20.6% of non-metastatic prostate cancer cases developed distant metastases after a median follow-up of 6.8 years. • The trends in the cumulative incidence of metastatic prostate cancer continuously increased up to 14 years of follow-up. • The study confirmed that distant metastatic prostate cancer can develop over the long term. • These results should help to inform the development of cancer services where they are most required.