Structural insights into Plasmodium PPIases
Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets. It is a well-known practice to adopt a chemo-genomics approach towards identifyi...
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Published in | Frontiers in cellular and infection microbiology Vol. 12; p. 931635 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
02.09.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets. It is a well-known practice to adopt a chemo-genomics approach towards identifying targets for known drugs, which can unravel a novel mechanism of action to aid in better drug targeting proficiency. Immunosuppressive drugs cyclosporin A, FK506 and rapamycin, were demonstrated to inhibit the growth of the malarial parasite,
Plasmodium falciparum
. Peptidyl prolyl
cis/trans
isomerases (PPIases), comprising cylcophilins and FK506-binding proteins (FKBPs), the specific target of these drugs, were identified in the
Plasmodium
parasite and proposed as an antimalarial drug target. We previously attempted to decipher the structure of these proteins and target them with non-immunosuppressive drugs, predominantly on FKBP35. This review summarizes the structural insights on
Plasmodium
PPIases, their inhibitor complexes and perspectives on drug discovery. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Felix Hausch, Darmstadt University of Technology, Germany Reviewed by: Thomas Atack, Broad Institute, United States; Manish Chauhan, Washington State University, United States This article was submitted to Bacteria and Host, a section of the journal Frontiers in Cellular and Infection Microbiology |
ISSN: | 2235-2988 2235-2988 |
DOI: | 10.3389/fcimb.2022.931635 |